Manufacturer |
NKMAX
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid in. 50mM MES buffer (pH 6.5) containing 30% glycerol |
Applications |
SDS-PAGE |
Amount |
20ug |
Item no. |
NKM-ATGP4020-20ug |
Targets |
NOG |
Conjugate/Tag |
His-Tag |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Antigen Species |
Human |
Bioassay Procedure |
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC |
Concentration |
0.25mg/ml (determined by Absorbance at 280nm) |
Description |
NOG, also known as noggin, is a secreted protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP) -signaling pathway. It binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. This protein is an inhibitor of several bone morphogenetic proteins and cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions. It also plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors. Recombinant human Noggin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
Domain |
28-232aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
HEK293 |
Gene Category |
Signal Transduction, Neuroscience |
General References |
Zimmerman LB., et al, (1996) Cell. 86:599-606. ; ; Groppe J., et al, (2002) Nature. 420:636-642. |
Internal Search Terms |
ATGP3369, ATGP4020-10ug, ATGP4020-20ug, ATGP4020-50ug, ATGP4020-100ug, ATGP4020-250ug, ATGP4020-500ug, ATGP4020-1mg, ATGP4020-10, ATGP4020-20, ATGP4020-50, ATGP4020-100, ATGP4020-250, ATGP4020-500, ATGP4020-1 |
Molecular Weight |
23.8kDa (211aa) |
Predicted nterm |
Gln |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.