Recombinant human TIE1 protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Tie-1, as known as tyrosine kinase with immunoglobulin like and EGF like domains 1, is an angiopoitein receptor. It is expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. However it has also been shown to be expressed in immature hematopoietic cells and platelets. It upregulates the cell adhesion molecules(CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Also, It has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. Recombinant human Tie-1, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Liquid. In 20mM Tris-HCl (pH 8.0) containing 0.1M NaCl, 50% glycerol

Signal Transduction

< 1 EU per 1ug of protein (determined by LAL method)

Human