Comparison

Recombinant human CCL2/MCP-1 protein

Item no. NKM-ATGP4067-250ug
Manufacturer NKMAX
Amount 250 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag HIS
Purity > 90% by SDS - PAGE
Sequence QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT<HHHH HH>
Citations Foresti ML, Arisi GM, et al. (2009). J Neuroinflammation. 6:40.
Semple BD, Bye N, et al. (2010). J Cereb Blood Flow Metab. 30:769-782.
NCBI NP_002973.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias C-C motif chemokine 2, CCL2, GDCF-2, HSMCR30, HC11, JE, MCAF, MCP-1, MCP1, Scya2, Sigje, SMC-CF, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Small-inducible cytokine A2
Similar products ATGP4067-10ug, ATGP4067-20ug, ATGP4067-50ug, ATGP4067-100ug, ATGP4067-250ug, ATGP4067-500ug, ATGP4067-1mg, ATGP4067-10, ATGP4067-20, ATGP4067-50, ATGP4067-100, ATGP4067-250, ATGP4067-500, ATGP4067-1
Available
Manufacturer - Type
Proteins
Manufacturer - Applications
SDS-PAGE, Bioactivity
Manufacturer - Category
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
9.5kDa (82aa)
Description
CCL2(Chemokine ligand 2), as known as MCP-1(monocyte chemotactic protein-1), is a small cytokine belonging to the CC chemokine family. This protein recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It binds to chemokine receptors CCR2 and CCR4. It also induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils, primarily due to interaction with CCR2 receptors on these cells. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. Recombinant human CCL2/JE/MCP-1, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.
Concentration
0.25mg/ml (determined by Absorbance at 280nm)
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Immunology, Hormones & Cytokines
Domain
24-99aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured its ability to chemoattract using THP-1 human acute monocytic leukemia cells. The ED50 range ≤ 30 ng/ml.
Predicted nterm
Gln 24
Species of Protein
Human
Manufacturer - Search Terms
ATGP4067-10ug, ATGP4067-20ug, ATGP4067-50ug, ATGP4067-100ug, ATGP4067-250ug, ATGP4067-500ug, ATGP4067-1mg, ATGP4067-10, ATGP4067-20, ATGP4067-50, ATGP4067-100, ATGP4067-250, ATGP4067-500, ATGP4067-1
Manufacturer - Alternative Names
SMC-CF, Small inducible cytokine subfamily A member 2, Small inducible cytokine A2, SCYA2, Monocyte secretory protein JE, Monocyte chemotactic protein 1 homologous to mouse Sig-je, Monocyte chemotactic and activating factor, MGC9434, MCP-1, MCP1, MCAF, HC11, GDCF-2, C-C motif chemokine ligand 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 250 ug
Available: In stock
available

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