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Recombinant human IL-2 (C145S) protein

Recombinant human IL-2 (C145S) protein

Item no.	NKM-ILB0501-100ug
Manufacturer	NKMAX
Amount	100 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MPTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFSQSIIS TLT
Citations	Morgan DA., et al. (1976). Science, 193. 1007-8. Watson J., et al. (1980). Immunol Rev, 51. 257-78. Taniguchi T., et al. (1983). Nature, 302. 305-10. Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009){https://pubmed.ncbi.nlm.nih.gov/19259669/} Koh J, et al. Susceptibility of CD24(+) ovarian cancer cells to anti-cancer drugs and natural killer cells. 9Biochem Biophys Res Commun. 2012){https://pubmed.ncbi.nlm.nih.gov/22995296/} Lee HM, et al. A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta. (Cell Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24879062/} Shin HW, et al. Role of c-Myb in the regulation of natural killer cell activity. (Biochem Biophys Res Commun. 2018){https://pubmed.ncbi.nlm.nih.gov/30103947/} Lee Y, et al. In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation. (J Innate Immun. 2020){https://pubmed.ncbi.nlm.nih.gov/32937636/} Lee YJ, et al. Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. (Int J Mol Sci. 2020){https://pubmed.ncbi.nlm.nih.gov/33339133/} Ko E, et al. ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4. (Stem Cell Res Ther. 2023){https://pubmed.ncbi.nlm.nih.gov/37964351/}
NCBI	NP_000577.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-2,TCGF,Aldesleukin,T-cell growth factor,Interleukin-2
Similar products	IL2 (C145S), ILB0501-10ug, ILB0501-20ug, ILB0501-50ug, ILB0501-100ug, ILB0501-250ug, ILB0501-500ug, ILB0501-1mg, ILB0501-10, ILB0501-20, ILB0501-50, ILB0501-100, ILB0501-250, ILB0501-500, ILB0501-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Bioactivity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	15.4 kDa (133aa) confirmed by MALDI-TOF
Description	IL-2, also known as T cell growth factor (TCGF), is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. This recombinant human IL-2 is a 15. 4 kDa protein, containing 133 amino acid residues including one intra chain disulfide bond. Recombinant human IL-2 was overexpressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration	0.5mg/ml (determined by Bradford assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4)
Antigen Species	Human
Gene Category	Hormones & Cytokines
Domain	22-153aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 range ≤0.65ng/ml.
Species of Protein	Human
Manufacturer - Search Terms	IL2 (C145S), ILB0501-10ug, ILB0501-20ug, ILB0501-50ug, ILB0501-100ug, ILB0501-250ug, ILB0501-500ug, ILB0501-1mg, ILB0501-10, ILB0501-20, ILB0501-50, ILB0501-100, ILB0501-250, ILB0501-500, ILB0501-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/31/2025

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