Comparison

Recombinant human IL-2 (C145S) protein

Item no. NKM-ILB0501-100ug
Manufacturer NKMAX
Amount 100 ug
Quantity options 100 ug 20 ug 500 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MPTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFSQSIIS TLT
Citations Morgan DA., et al. (1976). Science, 193. 1007-8.
Watson J., et al. (1980). Immunol Rev, 51. 257-78.
Taniguchi T., et al. (1983). Nature, 302. 305-10.

Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009){https://pubmed.ncbi.nlm.nih.gov/19259669/}
Koh J, et al. Susceptibility of CD24(+) ovarian cancer cells to anti-cancer drugs and natural killer cells. 9Biochem Biophys Res Commun. 2012){https://pubmed.ncbi.nlm.nih.gov/22995296/}
Lee HM, et al. A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta. (Cell Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24879062/}
Shin HW, et al. Role of c-Myb in the regulation of natural killer cell activity. (Biochem Biophys Res Commun. 2018){https://pubmed.ncbi.nlm.nih.gov/30103947/}
Lee Y, et al. In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation. (J Innate Immun. 2020){https://pubmed.ncbi.nlm.nih.gov/32937636/}
Lee YJ, et al. Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. (Int J Mol Sci. 2020){https://pubmed.ncbi.nlm.nih.gov/33339133/}
Ko E, et al. ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4. (Stem Cell Res Ther. 2023){https://pubmed.ncbi.nlm.nih.gov/37964351/}
NCBI NP_000577.2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias IL-2,TCGF,Aldesleukin,T-cell growth factor,Interleukin-2
Similar products IL2 (C145S), ILB0501-10ug, ILB0501-20ug, ILB0501-50ug, ILB0501-100ug, ILB0501-250ug, ILB0501-500ug, ILB0501-1mg, ILB0501-10, ILB0501-20, ILB0501-50, ILB0501-100, ILB0501-250, ILB0501-500, ILB0501-1
Available
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
15.4 kDa (133aa) confirmed by MALDI-TOF
Description
IL-2, also known as T cell growth factor (TCGF), is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. This recombinant human IL-2 is a 15. 4 kDa protein, containing 133 amino acid residues including one intra chain disulfide bond. Recombinant human IL-2 was overexpressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
22-153aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 range ≤0.65ng/ml.
Species of Protein
Human
Manufacturer - Search Terms
IL2 (C145S), ILB0501-10ug, ILB0501-20ug, ILB0501-50ug, ILB0501-100ug, ILB0501-250ug, ILB0501-500ug, ILB0501-1mg, ILB0501-10, ILB0501-20, ILB0501-50, ILB0501-100, ILB0501-250, ILB0501-500, ILB0501-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

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