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Recombinant human CD158e/KIR3DL1 protein

Recombinant human CD158e/KIR3DL1 protein

Item no.	NKM-KIR3004-20ug
Manufacturer	NKMAX
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology By Cell Type Carcinoma Hematology Myeloma Melanoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis Adenocarcinoma Cytoskeleton SDS-PAGE small GTPases Ras Subfamily RGK Subfamily
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 90% by SDS-PAGE
Sequence	MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP
Citations	Chan HW., et al. (2003) J. Exp. Med. 197(2), 245-55. Gardiner CM., et al . (2001) J Immunol. 166(5):2992-3001.
NCBI	NP_037421
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Killer cell immunoglobulin like receptor three Ig domains and long cytoplasmic tail 1,CD158 antigen-like family member E,HLA-BW4-specific inhibitory NK cell receptor,Natural killer-associated transcript 3,NKAT-3,p70 natural killer cell receptor clones CL-2/CL-11,p70 NK receptor CL-2/CL-11,cl-2,KIR,NKB1,cl-11,NKB1B,AMB11,CD158e1/2,CD158E1,CD158e2
Similar products	KIR3DL1, KIR3DS1, 1, CD1, CL2, KIR, NK receptor, CD158E1, MGC119726, MGC119728, MGC126589, MGC126591, NKAT3, NKB1, KIR antigen 3DL1, CD158E2, MHC class I NK cell receptor, Killer cell immunoglobulin-like receptor 3DL1, CD158 antigen-like family member E, CD158E, CD158e antigen, CD158E1/2, CL11, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains, short cytoplasmic tail, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, KIR G1, Kirl1, Kirl2, Krl1, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, NK-associated transcript 10, HLA-BW4-specific inhibitory NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, KIR3DL1 (Cytoplasmic tail, 361-444aa), Killer cell immunoglobulin-like receptor 3DL1 AMB11, NK-associated transcript
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	15 kDa (132aa) confirmed by MALDI-TOF
Description	The three Ig-domain from of inhibitory killer cell Ig-like receptor 1 (KIR3DL1, NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DL1 recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 25mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl
Antigen Species	Human
Gene Category	Immunology
Domain	361-444aa
Species of Protein	Human
Manufacturer - Search Terms	KIR3DL1, Killer cell immunoglobulin-like receptor 3DL1, KIR3DL1, CD158E, NKAT3, NKB1, KIR3DL1 (Cytoplasmic tail, 361-444aa), MHC class I NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, HLA-BW4-specific inhibitory NK cell receptor, CD1, Killer cell immunoglobulin-like receptor 3DL1, Killer cell immunoglobulin-like receptor 3DL1 AMB11, CD158 antigen-like family member E, CD158e antigen, CD158E1, CD158E1/2, CD158E2, CL11, CL2, HLA-BW4-specific inhibitory NK cell receptor, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains, short cytoplasmic tail, 1, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, KIR, KIR antigen 3DL1, KIR G1, KIR3DS1, Kirl1, Kirl2, Krl1, MGC119726, MGC119728, MGC126589, MGC126591, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, NK receptor, NK-associated transcript 10, NK-associated transcript
Manufacturer - Alternative Names	Killer cell immunoglobulin like receptor three Ig domains and long cytoplasmic tail 1, CD158 antigen-like family member E, HLA-BW4-specific inhibitory NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11, cl-2, KIR, NKB1, cl-11, NKB1B, AMB11, CD158e1/2, CD158E1, CD158e2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 ug

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Delivery expected until 10/2/2025

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