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Recombinant human Serpin E1/PAI-1 protein

Recombinant human Serpin E1/PAI-1 protein

Item no.	NKM-PAI0701-100ug
Manufacturer	NKMAX
Amount	100 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Senescence
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YT
Citations	Gorlatova NV., et al.(2007) J Biol Chem. 282(12):9288-96. Renckens R., et al. (2006) J Immunol. 177(11):8171-6. Cho KS, et al. Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity. (Glia. 2013){https://pubmed.ncbi.nlm.nih.gov/23378038/}
NCBI	NP_000593
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Plasminogen activator inhibitor-1,PLANH1,SERPINE1,PAI1,PLANH1,Plasminogen activator inhibitor-1,Plasminogen activator inhibitor-1
Similar products	SERPINE1, PAI1, PLANH1, Serpin E1, Plasminogen activator inhibitor-1, PAI0701-10ug, PAI0701-20ug, PAI0701-50ug, PAI0701-100ug, PAI0701-250ug, PAI0701-500ug, PAI0701-1mg, PAI0701-10, PAI0701-20, PAI0701-50, PAI0701-100, PAI0701-250, PAI0701-500, PAI0701-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Enzyme Activity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	45 kDa (400aa)
Description	Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) super family. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, the activators of plasminogen and hence fibrinolysis. PAI-1 is mainly produced by the endothelium but is also secreted by other tissue types, such as adipose tissue. Recombinant human PAI-1, fused to His tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 50mM NaAc (pH 5.5) containing 10% glycerol, 0.1M NaCl
Antigen Species	Human
Gene Category	Enzymes & Proteases
Domain	24-402aa
Bioactivity Comment Only	The IC50 for this effect is less than 3 nM, Measured by its ability to inhibit uPA cleavage of the substrate Z-GGR-AMC.
Species of Protein	Human
Manufacturer - Search Terms	Serpin E1, PAI1, Plasminogen activator inhibitor-1, PLANH1, SERPINE1, PAI1, PLANH1, Plasminogen activator inhibitor-1, Plasminogen activator inhibitor-1, PAI0701-10ug, PAI0701-20ug, PAI0701-50ug, PAI0701-100ug, PAI0701-250ug, PAI0701-500ug, PAI0701-1mg, PAI0701-10, PAI0701-20, PAI0701-50, PAI0701-100, PAI0701-250, PAI0701-500, PAI0701-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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NKM-PAI0701-100ug-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 7/31/2025

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