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Recombinant human PTP1B protein

Recombinant human PTP1B protein

Item no.	NKM-PTB2001-100ug
Manufacturer	NKMAX
Amount	100 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CL
Citations	Chernoff J., et al. (1990) Proc. Natl. Acad. Sci. uSA. 87, 2735-9 Kimura K, et al. Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. (Free Radic Biol Med. 2012){https://pubmed.ncbi.nlm.nih.gov/22824864/} Maeda A, et al. Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice. (Mol Nutr Food Res. 2014){https://pubmed.ncbi.nlm.nih.gov/24668740/} Quang TH, et al. Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata. (Molecules. 2015){https://pubmed.ncbi.nlm.nih.gov/26091075/} Naito Y. et al. Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction. (J Biol Inorg Chem. 2016){https://doi.org/10.1007/s00775-016-1364-9} Cho KH, et al. Isolation and structure determination of a new diketopiperazine dimer from marine-derived fungus Aspergillus sp. SF-5280. (Nat Prod Res. 2018){https://pubmed.ncbi.nlm.nih.gov/28670919/} Park JS, et al. Furanoaustinol and 7-acetoxydehydroaustinol: new meroterpenoids from a marine-derived fungal strain Penicillium sp. SF-5497. (J Antibiot (Tokyo). 2018){https://pubmed.ncbi.nlm.nih.gov/29463888/} VK Thu, et al. Protein tyrosine phosphatase 1B inhibitory triterpene glycosides from Mussaenda pilosissima Valeton. (Phytochemistry Letters. 2020){https://doi.org/10.1016/j.phytol.2020.01.023.} Kim HJ, et al. PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394. (Molecules. 2021){https://pubmed.ncbi.nlm.nih.gov/34576982/} Tran Thi Hong H, Iridoids from the aerial parts of Adenosma caeruleum with their nitric oxide inhibitory effects. (J Mol Struct. 2024){https://doi.org/10.1016/j.molstruc.2023.137149}
NCBI	NP_002818.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Protein tyrosine phosphatase non-receptor type 1,PTPN1,PTP1B,PTP-1B,Protein Tyrosine Phosphatase 1B,EC 3.1.3.48,Protein-tyrosine phosphatase1B,Tyrosine-protein phosphatase non-receptor type 1,Protein tyrosine phosphatase non-receptor type 1,Protein Tyrosine Phosphatase Non Receptor Type-1
Similar products	PTP-1B, PTPN1, PTP1B, Tyrosine-protein phosphatase non-receptor type 1, EC 3.1.3.48, Protein tyrosine phosphatase non-receptor type 1, Protein Tyrosine Phosphatase 1B, Protein-tyrosine phosphatase1B, Protein Tyrosine Phosphatase Non Receptor Type-1, PTB2001-10ug, PTB2001-20ug, PTB2001-50ug, PTB2001-100ug, PTB2001-250ug, PTB2001-500ug, PTB2001-1mg, PTB2001-10, PTB2001-20, PTB2001-50, PTB2001-100, PTB2001-250, PTB2001-500, PTB2001-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Enzyme Activity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	37.3 kDa (321aa)
Description	The protein coding region of the catalytic domain of PTP-1B (amino acids 1-321) was cloned into an E. coli expression vector. The catalytic domain of PTP-1B was overexpressed in E. coli as a soluble protein, and it was purified by conventional column chromatographic techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 25mM Tris-HCl buffer (pH 7.5) containing 2mM beta-mercaptoethanol, 1mM EDTA1mM DTT, 20% glycerol
Antigen Species	Human
Gene Category	Signal Transduction
Domain	1-321aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Specific activity is > 10, 000unit/mg, and is defined as the amount of enzyme that hydrolyze 1.0nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.
Species of Protein	Human
Manufacturer - Search Terms	PTP1B, Protein tyrosine phosphatase non-receptor type 1, PTPN1, PTP1B, PTP-1B, Protein Tyrosine Phosphatase 1B, EC 3.1.3.48, Protein-tyrosine phosphatase1B, Tyrosine-protein phosphatase non-receptor type 1, Protein tyrosine phosphatase non-receptor type 1, Protein Tyrosine Phosphatase Non Receptor Type-1, PTB2001-10ug, PTB2001-20ug, PTB2001-50ug, PTB2001-100ug, PTB2001-250ug, PTB2001-500ug, PTB2001-1mg, PTB2001-10, PTB2001-20, PTB2001-50, PTB2001-100, PTB2001-250, PTB2001-500, PTB2001-1
Manufacturer - Alternative Names	Protein tyrosine phosphatase non-receptor type 1, PTPN1, PTP1B, PTP-1B, Protein Tyrosine Phosphatase 1B, EC 3.1.3.48, Protein-tyrosine phosphatase1B, Tyrosine-protein phosphatase non-receptor type 1, Protein tyrosine phosphatase non-receptor type 1, Protein Tyrosine Phosphatase Non Receptor Type-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/31/2025

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