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Recombinant human alpha-Synuclein (A30P) protein

Recombinant human alpha-Synuclein (A30P) protein

Item no.	NKM-SNA2003-500ug
Manufacturer	NKMAX
Amount	500 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Infectious Diseases Viral Infections Coronavirus (COVID-19) By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Adenocarcinoma Autophagy SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 90% by SDS-PAGE
Sequence	MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Citations	Kruger R., et al. (1998) Nat Genet. 18, 106-108. Park, SM. et al. (2002) Blood. 100(7),2506-2514 Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/} Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012){https://pubmed.ncbi.nlm.nih.gov/22619171/} Konno M, et al. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012){https://pubmed.ncbi.nlm.nih.gov/22892036/}
NCBI	NP_000336.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SNCA,NACP,PARK1,PARK4,PD1,α-synuclein Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,Parkinson disease 4,autosomal dominant Lewy body
Similar products	Alpha synuclein, alpha-Synuclein, SNCA, NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PD1, MGC110988, PARK4, Synuclein alpha, alphaSYN, MGC105443, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, PARK 4, Parkinson disease familial 1, PD 1, Alpha-synuclein isoform NACP140, precursor of PARK 1, a-Synuclein (A30P), SNA2003-10ug, SNA2003-20ug, SNA2003-50ug, SNA2003-100ug, SNA2003-250ug, SNA2003-500ug, SNA2003-1mg, SNA2003-10, SNA2003-20, SNA2003-50, SNA2003-100, SNA2003-250, SNA2003-500, SNA2003-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	14.4 kDa (140aa) confirmed by MALDI-TOF
Description	A Parkinson's disease-related point mutant (A30P) of alpha-synuclein. A30P mutant of alpha-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 10% glycerol
Antigen Species	Human
Gene Category	Neuroscience
Domain	1-140aa
Species of Protein	Human
Manufacturer - Search Terms	a-Synuclein (A30P), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA2003-10ug, SNA2003-20ug, SNA2003-50ug, SNA2003-100ug, SNA2003-250ug, SNA2003-500ug, SNA2003-1mg, SNA2003-10, SNA2003-20, SNA2003-50, SNA2003-100, SNA2003-250, SNA2003-500, SNA2003-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 7/31/2025

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