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Recombinant human beta-Synuclein protein

Recombinant human beta-Synuclein protein

Item no.	NKM-SNB2001-500ug
Manufacturer	NKMAX
Amount	500 ug
Quantity options	100 ug 20 ug 500 ug
Category	Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Citations	Jakes R., et al. (1994) FEBS lett. 345, 27-32. Kim J.,et al. (1997) Molecules and Cells. 7, 78-83. Hashimoto M., et al. (2001) Neuron 32, 213-223. Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006){https://pubmed.ncbi.nlm.nih.gov/16524375/} JY Park, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/} Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010){https://pubmed.ncbi.nlm.nih.gov/20448034/} Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011){https://pubmed.ncbi.nlm.nih.gov/21985244/} Konno M, et al. Suppression of dynamin GTPase decreases a-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012){https://pubmed.ncbi.nlm.nih.gov/22892036/} Førland MG, et al. Validation of a new assay for α-synuclein detection in cerebrospinal fluid. (Clin Chem Lab Med. 2017){https://pubmed.ncbi.nlm.nih.gov/27474841/} Kobayashi J, et al. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. (FASEB J. 2019){https://pubmed.ncbi.nlm.nih.gov/31211923/}
NCBI	NP_001001502.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Beta-synuclein,SNCB beta-Synuclein,B-synuclein,Phosphoneuroprotein 14,PNP14,Synuclein beta
Similar products	Phosphoneuroprotein 14, Beta-synuclein, Synuclein beta, PNP14, Beta synuclein, beta synuclein, b-Synuclein, SNCB beta-Synuclein, B-synuclein, SNB2001-10ug, SNB2001-20ug, SNB2001-50ug, SNB2001-100ug, SNB2001-250ug, SNB2001-500ug, SNB2001-1mg, SNB2001-10, SNB2001-20, SNB2001-50, SNB2001-100, SNB2001-250, SNB2001-500, SNB2001-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	14.2 kDa (134aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description	beta-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. beta-synucelin also has a chaperone-like activity. Recently, beta-synuclein has been suggested to inhibit
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
Antigen Species	Human
Gene Category	Neuroscience
Domain	1-134aa
Species of Protein	Human
Manufacturer - Search Terms	b-Synuclein, Beta-synuclein, SNCB beta-Synuclein, B-synuclein, Beta synuclein, beta synuclein, Phosphoneuroprotein 14, PNP14, Synuclein beta, SNB2001-10ug, SNB2001-20ug, SNB2001-50ug, SNB2001-100ug, SNB2001-250ug, SNB2001-500ug, SNB2001-1mg, SNB2001-10, SNB2001-20, SNB2001-50, SNB2001-100, SNB2001-250, SNB2001-500, SNB2001-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 9/4/2025

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