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Recombinant human TRAIL/TNFSF10 protein

Recombinant human TRAIL/TNFSF10 protein

Item no.	NKM-TRA0801-20ug
Manufacturer	NKMAX
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis SDS-PAGE Cardiovascular Research Ischemia & Reperfusion Injury
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG
Citations	Janssen EM., et al. (2005). Nature. 434(7029):88-93. Deocaris CC., et al. (2007) Ann N Y Acad Sci. 1119:165-75 Park Dain, et al. Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells. (Journal of Natural Products. 2016){https://pubmed.ncbi.nlm.nih.gov/26829656/} Kim J, et al. Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. (Br J Pharmacol. 2016){https://pubmed.ncbi.nlm.nih.gov/26661339/} Kim EO, et al. CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. (Int J Mol Med. 2020){https://pubmed.ncbi.nlm.nih.gov/31894259/} Kim JH, et al. Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer. (Exp Mol Med. 2024){https://pubmed.ncbi.nlm.nih.gov/38684915/}
NCBI	NP_003801.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor necrosis factor ligand superfamily member 10,Apo-2 ligand,Apo-2L,TNF-related apoptosis-inducing ligand,Protein TRAIL,CD253,APO2L,TL2,TANCR
Similar products	TRAIL, TNFSF10, TRA0801-10ug, TRA0801-20ug, TRA0801-50ug, TRA0801-100ug, TRA0801-250ug, TRA0801-500ug, TRA0801-1mg, TRA0801-10, TRA0801-20, TRA0801-50, TRA0801-100, TRA0801-250, TRA0801-500, TRA0801-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	19.6 kDa (169aa)
Description	TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL-R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRuNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRuNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Recombinant human TRAIL was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 10% glycerol, 0.3M NaCl, 0.1mM DTT
Antigen Species	Human
Gene Category	Cancer
Domain	114-281aa
Species of Protein	Human
Manufacturer - Search Terms	TRAIL, TNFSF10, TRA0801-10ug, TRA0801-20ug, TRA0801-50ug, TRA0801-100ug, TRA0801-250ug, TRA0801-500ug, TRA0801-1mg, TRA0801-10, TRA0801-20, TRA0801-50, TRA0801-100, TRA0801-250, TRA0801-500, TRA0801-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 ug

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Delivery expected until 7/31/2025

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