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FAS Recombinant Protein (Human)

FAS Recombinant Protein (Human)

Item no.	OPED00042
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Metabolism Cholesterol & Lipid Metabolism By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis ELISA Enzymes Fatty Acid Synthesis Immunostaining
Type	Proteins Recombinant
Format	Lyophilized
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Purity	>95% (SDS-PAGE)
Citations	Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract; Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection: W. Hou, et al.; J. Exp. Med. 206, 313 (2009), Abstract; Full Text High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis: K. Roessner, et al.; J. Immunol. 170, 2702 (2003), Abstract; Full Text Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003), Abstract; Full Text Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death: F. Petit et al; J. Biol. Chem. 277, 1477 (2002), Abstract; Full Text Mechanisms underlying neuronal death induced by chromogranin A-activated microglia: J. Ciesielski-Treska, et al.; J. Biol. Chem. 276, 13113 (2001), Abstract; Full Text T cell costimulation by the TNF ligand BAFF: B. Huard et al.; J. Immunol. 167, 6225 (2001), Abstract; Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL: J.L. Bodmer, et al.; J. Biol. Chem. 275, 20632 (2000), Abstract; Full Text Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract; TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia: R. Schlapbach, et al.; Eur. J. Immunol. 30, 3680 (2000), Abstract; Characterization of Fas (Apo-1, CD95)-Fas ligand interaction: P. Schneider, et al.; J. Biol. Chem. 272, 18827 (1997), Abstract; Full Text
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ALPS1A;APO-1;Apo-1 antigen;APO-1 cell surface antigen;apoptosis antigen 1;apoptosis signaling receptor FAS;apoptosis-mediating surface antigen FAS;APT1;CD95;CD95 antigen;Fas (TNF receptor superfamily,member 6);Fas AMA;FAS1;FASLG receptor;FASTM;mutant tumor necrosis receptor superfamily member 6;TNF receptor superfamily member 6;TNFRSF6;tumor necrosis factor receptor superfamily member 6;tumor necrosis factor receptor superfamily,member 6.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	56 kDa
Manufacturer - Application Additional Information	ELISA: binds to FasL at 10-100 ng/ml.
Gene symbol	FAS
Gene Fullname	Fas cell surface death receptor
Protein size	Recombinant
Product format	Lyophilized. Contains PBS.
Reconstitution and storage	Reconstitute with 50 ul sterile water. Further dilutions can be made with medium containing 5% fetal calf serum or a carrier protein. Store at -20C
Description of target	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Nucleotide accession_num	NM_001127891.2
Protein accession_num	NP_001121363.1
Protein name	Tumor necrosis factor receptor superfamily member 6
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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