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FASLG Recombinant Protein (Human)

FASLG Recombinant Protein (Human)

Item no.	OPED00043
Manufacturer	AVIVA Systems Biology
Amount	10 ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis ELISA Immunostaining
Type	Proteins Recombinant
Format	Lyophilized
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Purity	>95% (SDS-PAGE)
Citations	Role of the cell cycle in regression of the corpus luteum: S.M. Quirk, et al.; Reproduction 145, 161 (2013), Application(s): Death induction of bovine luteal cells, Abstract; Full Text The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs: R. Herrero, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 305, L377 (2013), Application(s): Death induction of primary mouse alveolar epithelial and endothelial cells, Abstract; A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood 117, 5953 (2011), Application(s): Death induction of murine bone marrow neutrophils, Abstract; Full Text Different Signaling Pathways Stimulate a Disintegrin and Metalloprotease-17 (ADAM17) in Neutrophils during Apoptosis and Activation: Y. Wang, et al.; J. Biol. Chem. 286, 38980 (2011), Application(s): Death induction of Jurkat cells, Abstract; Full Text A role for cFLIP in B cell proliferation and stress MAPK regulation: H. Zhang, et al.; J. Immunol. 182, 207 (2009), Abstract; Full Text Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas: V. Anathy, et al.; J. Cell Biol. 184, 241 (2009), Application(s): Death induction of C10 cells, Fibroblasts and CD4+ T lymphocytes, Abstract; Full Text Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function: F.L. Scott, et al.; J. Biol. Chem. 283, 19499 (2008), Application(s): Death induction of primary mouse thymocytes, Abstract; Full Text Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development: V. Labi, et al.; J. Exp. Med. 205, 641 (2008), Abstract; Full Text CD4-Dependent Signaling Is Required for a Late Checkpoint during Th2 Development Associated with Resistance to Activation-Induced Cell Death: Z. Tatari-Calderone, et al.; J. Immunol. 175, 5629 (2005), Application(s): Death induction of murine T cells, Abstract; Full Text Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy: C. Gajate & F. Mollinedo; J. Biol. Chem. 280, 11641 (2005), Abstract; Full Text Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion: M. C. Michallet, et al.; Blood 102, 3719 (2004), Abstract; The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF: A. Tardivel, et al.; Eur. J. Immunol. 34, 509 (2004), Abstract; A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha -chemoattractant for T cell chemotaxis toward epidermis in: S. Klunker, et al.; J. Immunol. 171, 1078 (2003), Abstract; Full Text Theileria parva-Transformed T Cells Show Enhanced Resistance to Fas/Fas Ligand-Induced Apoptosis : P. KÃ¼enzi, et al.; J. Immunol. 171, 1224 (2003), Application(s): Death induction of Theileria parva-infected TpM(803) T cells, Abstract; Full Text BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase: J.R. Tumang, et al.; J. Immunol. 168, 2712 (2002), Abstract; Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway: D. Vermijlen, et al.; J. Leukoc. Biol. 72, 668 (2002), Application(s): Death induction of P815 cells, Abstract; Full Text Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant-associated intimal hyperplasia: M. Sata, et al.; J. Immunol. 166, 6964 (2001), Abstract; Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway: D. Siegmund, et al.; J. Biol. Chem. 276, 32585 (2001), Abstract; Full Text Mechanisms underlying neuronal death induced by chromogranin A-activated microglia: J. Ciesielski-Treska, et al.; J. Biol. Chem. 276, 13113 (2001), Abstract; Full Text T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001), Abstract; Crosstalk Between Keratinocytes and T Lymphocytes via Fas/Fas Ligand Interaction: Modulation by Cytokines: R. Arnold, et al.; J. Immunol. 162, 7140 (1999), Application(s): Death induction of Jurkat cells, Abstract; Full Text Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition: T.Z. Zaks, et al.; J. Immunol. 162, 3273 (1999), Application(s): Death induction of tumor-specific CD8+ T cells, Abstract; Full Text Inhibition of Toxic Epidermal Necrolysis by Blockade of CD95 with Human Intravenous Immunoglobulin: I. Viard, et al.; Science 282, 490 (1998), Application(s): Death induction of human keratinocytes, Abstract; Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants: A.R. Thilenius, et al.; Eur. J. Immunol. 27, 1108 (1997), Abstract; Characterization of Fas (Apo-1, CD95)-Fas ligand interaction: P. Schneider, et al.; J. Biol. Chem. 272, 18827 (1997), Abstract; Full Text
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ALPS1B;apoptosis (APO-1) antigen ligand 1;apoptosis antigen ligand;APT1LG1;APTL;CD178;CD95 ligand;CD95L;CD95-L;fas antigen ligand;Fas ligand (TNF superfamily,member 6);FASL;mutant tumor necrosis factor family member 6;TNFSF6;TNLG1A;tumor necrosis factor ligand 1A;tumor necrosis factor ligand superfamily member 6.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	32 kDa, 35 kDa (glycosylated)
Manufacturer - Application Additional Information	ELISA: binds to Fas receptor at 1-100 ng/ml.
Gene symbol	FASLG
Gene Fullname	Fas ligand
Protein size	Recombinant
Product format	Lyophilized. Contains PBS.
Reconstitution and storage	Reconstitute with 100 ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. Store at -20C
Description of target	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).
Nucleotide accession_num	NM_002422.4
Protein accession_num	NP_002413.1
Protein name	Tumor necrosis factor ligand superfamily member 6
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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