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HDAC1 Recombinant Protein (Human)

HDAC1 Recombinant Protein (Human)

Item no.	OPED00053
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Metabolism Diabetes Regulation of Appetite Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Epigenetics By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Senescence Astrocytoma By Organ Bladder Cancer Bone Cancer
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Insect Cells
Dry ice	Yes
Citations	Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors: W.H. Huang, et al.; Eur. J. Med. Chem. 46, 4042 (2011), Abstract; Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin: X. Li et al.; Cancer Res. 66, 9323 (2006), Abstract; Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer: A. J. Wilson et al.; J. Biol. Chem. 281, 13548 (2006), Abstract; Acetylation and deacetylation of non-histone proteins: M. A. Glozak et al.; Gene 363, 15 (2005), Abstract; Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*: Z. Zhang et al.; Breast Cancer Res. Treat. 94, 11 (2005), Abstract; Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer: K. Halkidou; Prostate 59, 177 (2004), Abstract; Histone deacetylases (HDACs): characterization of the classical HDAC family: A. J. de Ruijter et al.; Biochem. J. 370, 737 (2003), Abstract; SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities: G. David et al.; J. Biol. Chem. 277, 23658 (2002), Abstract; CoREST is an integral component of the CoREST- human histone deacetylase complex: A. You et al.; PNAS 98, 1454 (2001), Abstract; Expression profile of histone deacetylase 1 in gastric cancer tissues: J. H. Choi et al.; Jpn. J. Cancer Res. 92, 1300 (2001), Abstract; Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation: M. K. Pflum et al.; J. Biol. Chem. 276, 47733 (2001), Abstract; Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1: G. W. Humphrey et al.; J. Biol. Chem. 276, 6817 (2001), Abstract; Deacetylation of p53 modulates its effect on cell growth and apoptosis: J. Luo et al.; Nature 408, 377 (2000), Abstract; Histone deacetylases specifically down-regulate p53-dependent gene activation: L. J. Juan et al.; J. Biol. Chem. 275, 20436 (2000), Abstract; Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation: Y. Zhang et al.; Genes Dev. 13, 1924 (1999), Abstract; Three proteins define a class of human histone deacetylases related to yeast Hda1p: C. M. Grozinger et al.; PNAS 96, 4868 (1999), Abstract; Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression: C. D. Laherty et al.; Cell 89, 349 (1997), Abstract; Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family: W. M. Yang et al.; J. Biol. Chem. 272, 44 (1997), Abstract; A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p: J. Taunton et al.; Science 272, 408 (1996), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GON-10;HD1;histone deacetylase 1;KDAC1;reduced potassium dependency,yeast homolog-like 1;RPD3;RPD3L1.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	55 kDa
Gene symbol	HDAC1
Gene Fullname	histone deacetylase 1
Protein size	Recombinant
Product format	Liquid. In 50mM TRIS, pH 8.0, 138mM sodium chloride and 10% glycerol.
Reconstitution and storage	Store at -80C
Description of target	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Nucleotide accession_num	NM_000603.4
Protein accession_num	NP_000594.2
Protein name	Histone deacetylase 1
Purification	Partially purified by single-step affinity chromatography and gel filtration.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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