Soluble TNF Receptor Type I Recombinant Protein

Recombinant Proteins

The lyophilized Soluble TNF Receptor Type I recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Soluble TNF Receptor Type I is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Soluble TNF Receptor Type I recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFκ B, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.

4507575

Homo sapiens

Human