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GDF-5 Recombinant Protein

GDF-5 Recombinant Protein

Manufacturer	ProSci
Category	Neuroscience Neural Lineage Markers Neural Signaling Peptides & Proteins Recombinant Proteins Neuron Nuclear Markers
Type	Proteins Recombinant
Specific against	other
Format	Lyophilized
Amount	0.01 mg
Item no.	PRS-40-579-0.01mg
eClass 6.1	34160400
eClass 9.0	42020190
Available
Storage Conditions	The lyophilized GDF-5 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted GDF-5 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing GDF-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Disclaimer	This product is for research use only.
Purity	Greater than 98% by SDS-PAGE gel and HPLC analyses.
Background	GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
Accession #	NP_000548.1
Ncbi Gene Id #	8200
Ncbi Official Symbol	GDF5
Ncbi Official Full Name	growth differentiation factor 5
Ncbi Organism	Homo sapiens
Swissprot #	P43026
Sequence	APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Biological Activity	Endotoxin level is less than 0.1 ng per μ g (1EU/μ g).
Protein Gi#	4503969
Peptide Sequence	APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.01 mg

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Delivery expected until 6/6/2024