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VTCN1 Recombinant Protein

VTCN1 Recombinant Protein

Item no.	PRS-96-049-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Western Blot Cytoskeleton Markers
Type	Proteins Recombinant
Format	Lyophilized
Applications	WB
Specific against	other
Conjugate/Tag	HIS
Purity	>90% as determined by SDS-PAGE.
Sequence	Phe 29 - Ala 258
Citations	Salceda S., et al., 2005, Exp. Cell Res. 306:128-141. Kryczek I., et al., 2006, J. Exp. Med. 203:871-881. Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.
NCBI	VTCN1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	B7-H4,VTCN1,B7S1,B7h.5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight	26.4 kDa
Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized Human B7-H4, His Tag at 2 ug/mL can bind anti-B7-H4 mAb (Human IgG1) with a linear range of 0.4-6 ng/mL.
Background	V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
By Type	Cancer, Innate Immunity
Buffer	PBS, pH 7.4
Application Note	This recombinant protein can be used for WB. For research use only.
NCBI Official Name	V-set domain containing T cell activation inhibitor 1
NCBI Organism	homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 2/5/2026

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