Manufacturer |
ProSci
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Lyophilized |
Applications |
WB |
Amount |
0.1 mg |
Item no. |
PRS-96-171-0.1mg |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Applications |
This recombinant protein can be used for WB. For research use only. |
Applications |
This recombinant protein can be used for WB. For research use only. |
Buffer |
PBS, pH7.4 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
39.2 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Background |
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2. |
1St Image Caption3 |
Human CD3 epsilon, Fc, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Background References 1 |
Gold DP, et al., 1986, Nature 321 (6068): 431–4. |
Background References 2 |
Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. |
Background References 3 |
de Saint Basile G, et al., 2004, J. Clin. Invest. 114 (10): 1512–7. |
Background References 4 |
Wong S, et al., 1991, Clin. Exp. Immunol. 83 (1): 69–73. |
Accession # |
NP_000724.1 |
Ncbi Gene Id # |
916 |
Ncbi Official Symbol |
CD3E |
Ncbi Official Full Name |
CD3e molecule, epsilon (CD3-TCR complex) |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P07766 |
Fusion Tag |
C-Fc, His Tag |
Sequence |
Asp 23 - Asp 126 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.