Anti-IL-8 / CXCL8 Antibody

ELISA (dilution: 0.1, 0.2ug/ml), Immunofluorescence, Immunohistology - Paraffin, Western Blotting

Ambient temperature

Rabbit Anti-Human IL-8 / CXCL8

Phosphate buffered saline

Purified IgG - lyophilized

Reconstitute with 0.1 ml distilled water

This product is specific for human IL-8 (Interleukin-8), a 72 amino acid pro-inflammatory CXC chemokine designated CXCL8, secreted by endothelial cells and monocytes, which acts as a major chemoattractant for neutrophils and also T cells and basophils. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours. Previous nomenclature for IL-8 includes neutrophil activating protein 1(NAP-1), granulocyte chemotactic protein 1 (GCP-1), Monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C.

Antisera to human IL-8 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.