Anti-SNAP-25 (C-term) Antibody

Antibodies|Primary Antibodies

-20°C

Purified IgG - liquid

SNAP-25

IgG concentration 0.5 mg/ml (lot specific)

This product detects an epitope within the C-terminal (CT) of human synaptosomal-associated protein, 25kD (SNAP-25). SNAP-25 is a presynaptic plasma membrane protein which is essential for Ca2+-regulated exocytosis of neurotransmitters. SNAP-25 has been shown to bind to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release. SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis. This product is expected to recognize both isoforms. SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, whilst SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms.

Peptide sequence C-DEANQRATKMLGSG corresponding to the C-terminus of SNAP-25 (NP_003072.2, NP_570824.1).