Anti-FAP alpha Antibody

Antibodies|Primary Antibodies

-20°C

12352203

FAP alpha

IgG concentration 0.5 mg/ml

This product detects fibroblast activation protein alpha (FAP alpha), a type II membrane protein belonging to the serine protease family. FAP alpha is upregulated on activated fibroblasts in response to wounding, and may also be involved in epithelial-mesenchymal interactions during development and tissue repair. Active FAP alpha is a 170kD homodimeric protein which can also exist as a soluble form. FAP alpha can also form heterodimeric complexes with CD26 (DPP4), and these proteins may function co-ordinately to modulate the growth, differentiation, adhesion and metastasis of tumour cells.

Antisera to FAP alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.