Anti-Mouse NK-1.1 Ag. Antibody

Antibodies|Primary Antibodies

-20°C

12352203

Natural Killer Cells

IgG concentration 1.0 mg/ml

This antibody recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family.In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that the antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by the antibody appears to be even more complex, as only some CD161b positive strains are labelled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. activation of NK cells.

Spleen and bone marrow cells from CE mice