Anti-CD107b Antibody, FITC

Antibodies|Primary Antibodies

-20°C

Mouse Anti-CD107b [+FITC] (0.1 mg)

Dog, Human, Mink

CD107b

IgG concentration 0.1mg/ml (lot specific)

This product recognizes canine CD107b, otherwise known as LAMP-2, a 95kDa heavily-glycosylated type I integral lysosomal glycoprotein, shown to share high N-terminal amino acid sequence homology with human, mouse and rat CD107b.Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion. Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumour cells and their metastatic potential.