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FNDC4, Human/mouse recombinant

FNDC4, Human/mouse recombinant

Item no.	268-11160-1
Manufacturer	Raybiotech
Amount	10 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Purity	>95% determined by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Fibronectin Type III Domain-containing Protein 4,Fibronectin Type III Repeat-containing Protein 1
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Protein
Shipping Temperature	Gel Pack
Storage Conditions	The protein may be stored for 6 months at -20° C
Molecular Weight	ca.16.0 kDa. (Extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.
Gene Symbols	FNDC4
Reconstitution	Reconstitute with 100 ul sterile distilled water.
Endotoxin Level	<0.1 EU/ug by LAL method
Introduction	Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.
Country of Animal Origin	USA

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