Recombinant Mouse INTERLEUKIN-1 BETA

ELISA (0.2-0.4ng/well), Functional Assays, Western Blotting (1.5-3.0ng/lane), ELISA (0.2-0.4ng/well), Functional Assays, Western Blotting (1.5-3.0ng/lane)

Ambient temperature

17.5kD (153 amino acid residues)

12352202

Purified recombinant protein - lyophilized

Reconstitute with 0.1ml distilled water.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution.

None present

Interleukin-1 beta (IL-1 beta), is a 17.5 kDa proinflammatory, cell-associated cytokine, produced by monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1 beta promotes the proliferation of memory T cells and cytokine production. It attenuates regulatory T cell function and enables CD4+CD25- autoreactive effectors to avoid suppression. IL-1 beta signals downstream of myc and is required for angiogenesis and invasiveness of tumour cells. IL-1 beta is directly involved in neuronal injury in neurodegenerative disorders, and stimulates mitogenic FGF-like activity, bone resorption and promotes the release of collagenase and prostaglandin from synovial cells.