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Ryuvidine

Ryuvidine

Item no.	HY-100624-5mg
Manufacturer	MedChem Express
CASRN	265312-55-8
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.40
Citations	[1]Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. \|[2]Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9(11):2471-8. \|[3]FitzGerald J, et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One. 2014 Jun 5;9(6):e98891.\|[4]Ali R, et al. Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2. Cells. 2021 May 24;10(6):1303.\|[5]Cotti S, et al. More bone with less minerals: the effects of dietary phosphorus on the zebrafish skeleton[C]//49th European Calcified Tissue Society Congress (ECTS 2022). 2022, 16: 59-60.
Smiles	O=C1C=C(C(C2=C1SC(C)=N2)=O)NC3=CC=C(C)C=C3
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK; DNA/RNA Synthesis; Histone Demethylase; Histone Methyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	284.33
Product Description	Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM. Ryuvidine also inhibits KDM5A and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	CDK4
Clinical information	No Development Reported

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HY-100624-5mg-safety-datasheet.pdf