NEO214

Item no.	HY-124582-10mM
Manufacturer	MedChem Express
CASRN	1361198-80-2
Amount	10 mM/1 mL
Quantity options	1 ea 100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	98.0
Citations	[1]Ou M, et al. Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate. Autophagy. 2023 Dec;19(12):3169-3188.
Smiles	O=C(N1C(CC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1)=O)OCC4=CC[C@@H](C(C)=C)CC4
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; mTOR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	453.57
Product Description	NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; PI3K/Akt/mTOR
Clinical information	No Development Reported

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HY-124582-10mM-safety-datasheet.pdf