« Back
Home /
Taurodeoxycholate (sodium salt) (Standard)

Taurodeoxycholate (sodium salt) (Standard)

Item no.	HY-128853R-50mg
Manufacturer	MedChem Express
CASRN	1180-95-6
Amount	50 mg
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Standards, Ladders & Markers Other Standards
Type	Standard
Specific against	other
Citations	[1]Villavicencio-Queijeiro A, et al. The fully-active and structurally-stable form of the mitochondrial ATP synthase of Polytomella sp. is dimeric. J Bioenerg Biomembr. 2009 Feb;41(1):1-13.\|[2]Kispal G, et al. Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane. J Biol Chem. 1986 Oct 25;261(30):14209-13. \|[3]Choi HJ, et al. Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats. Drug Chem Toxicol. 2021 May;44(3):268-276.\|[4]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41. \|[5]Gertzen CG, et al. Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists. Eur J Med Chem. 2015 Nov 2;104:57-72. \|[6]Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9.\|[7]Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. \|[8]Yamaguchi J, et al. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery. 2004 Feb;135(2):215-21.\|[9]Zou Y, et al. Taurodeoxycholate ameliorates DSS-induced colitis in mice. Int Immunopharmacol. 2023 Sep;122:110628.\|[10]Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60. \|[11]Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6. \|[12]Chang S, et al. Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front Immunol. 2018 Sep 18;9:1984.
Smiles	C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference Standards
Manufacturer - Targets	Apoptosis; Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1; NF-κB; PARP; PKA; Reference Standards
Shipping Temperature	Room temperature
Molecular Weight	521.69
Product Description	Taurodeoxycholate sodium salt (Standard) is a bile salt (Standard)-related anionic detergent. Taurodeoxycholate sodium salt (Standard) is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt (Standard) is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question