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Wy-45494 (hydrochloride) (Standard)

Wy-45494 (hydrochloride) (Standard)

Item no.	HY-131527R-50mg
Manufacturer	MedChem Express
CASRN	93413-90-2
Amount	50 mg
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers Other Standards
Type	Standard
Specific against	other
Purity	99.85
Citations	[1]Otton, et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br. J. Clin. Pharmacol. 41(2), 149-156 (1996).
Smiles	OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Alias	N-Desmethyl Venlafaxine (hydrochloride) (Standard),Wy 45494 (Standard)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference Standards
Manufacturer - Targets	Reference Standards; Serotonin Transporter
Shipping Temperature	Blue Ice
Storage Conditions	4°C, sealed storage, away from light and moisture
Molecular Weight	299.84
Product Description	Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Manufacturer - Research Area	Metabolic Disease
Manufacturer - Pathway	Neuronal Signaling; Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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