L5-DA

Item no.	HY-144712-1mg
Manufacturer	MedChem Express
CASRN	2986876-41-7
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.03
Citations	[1]Wang Y, et al. A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology. Bioorg Med Chem. 2021;48:116416.
Smiles	CN(CCOC1=CC2=C(N(C=C2)C3=CC=C4C=CC(N5C=CC6=C5C=CC(OCCN(C)C)=C6)=NC4=N3)C=C1)C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; G-quadruplex
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	534.65
Product Description	L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Clinical information	No Development Reported

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