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Amifampridine (Standard)

Amifampridine (Standard)

Item no.	HY-14946R-50mg
Manufacturer	MedChem Express
CASRN	54-96-6
Amount	50 mg
Quantity options	1 ea 100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Standards, Ladders & Markers Other Standards
Type	Standard
Specific against	other
Citations	[1]Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10(12):1098-107.\|[2]T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90.\|[3]Ojala KS, et al. A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021 Jan-Jun;296:100302.
Smiles	NC1=C(N)C=CN=C1
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Alias	3,4-Diaminopyridine (Standard)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference Standards
Manufacturer - Targets	Potassium Channel; Reference Standards
Shipping Temperature	Room temperature
Molecular Weight	109.132
Product Description	Amifampridine (Standard) is the analytical standard of Amifampridine. This product is intended for research and analytical applications. Amifampridine (3, 4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3].
Manufacturer - Research Area	Neurological Disease
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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