JI069

Item no.	HY-167692-25mg
Manufacturer	MedChem Express
CASRN	850019-35-1
Amount	25 mg
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Citations	[1]A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen-induced arthritis in vivo
Smiles	O=C(C1=C(NC(COC(CC2=C(Cl)C=CC=C2Cl)=O)=O)SC=C1)N
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	STAT
Shipping Temperature	Room temperature
Molecular Weight	387.24
Product Description	JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.
Manufacturer - Research Area	Others
Manufacturer - Pathway	JAK/STAT Signaling; Stem Cell/Wnt
Clinical information	No Development Reported

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