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(E/Z)-THZ1 (dihydrochloride)

(E/Z)-THZ1 (dihydrochloride)

Item no.	HY-80013B-10mg
Manufacturer	MedChem Express
CASRN	2095433-94-4
Amount	10 mg
Quantity options	1 ea 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Citations	[1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511(7511):616-620.\|[2]Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59(4):576-587.
Smiles	O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5.[H]Cl.[H]Cl
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK
Shipping Temperature	Room temperature
Molecular Weight	638.97
Product Description	(E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC 50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect [1] [2] .
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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