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1,11b-Dihydro-11b-hydroxymedicarpin

1,11b-Dihydro-11b-hydroxymedicarpin

Item no.	HY-N0976-5mg
Manufacturer	MedChem Express
CASRN	210537-04-5
Amount	5 mg
Quantity options	100 mg 1 ea 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Alejandro F.Barrero, et al. Pterocarpans from <i>Ononis viscosa</i> subsp. <i>breviflora</i>. Phytochemistry. 1998 May, 48 (1): 187-190.\|[2]Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541.\|[3]Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.
Smiles	O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	11b-Hydroxy-11b,1-dihydromedicarpin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Interleukin Related; Wnt
Shipping Temperature	Room temperature
Molecular Weight	288.30
Product Description	1, 11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b, 1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Immunology/Inflammation; Stem Cell/Wnt
Clinical information	No Development Reported

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