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PF-7006

PF-7006

Item no.	TMO-T200142-25mg
Manufacturer	TargetMol
CASRN	2771955-09-8
Amount	25 mg
Quantity options	100 mg 100 mg 25 mg 25 mg 50 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	N#CC1=CNC2=NC(=NC(NC3CCOCC3)=C12)NC4=CC=C(N=C4C)N5CCOCC5
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	434, 49
Description	PF-7006, an Mps1 kinase inhibitor, exhibits a Ki value of 0.27 nM and an IC50 value of 2.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reduces histone H3 levels, and shortens the duration of mitosis, thereby inducing apoptosis (Apoptosis) in cancer cells. When used in combination with Palbociclib, the tolerance of cancer cells to PF-7006 is enhanced. PF-7006 is applicable for research on breast cancer.
Pathways	Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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