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Nutlin-3

Nutlin-3

Item no.	TMO-T2158-1mg
Manufacturer	TargetMol
CASRN	548472-68-0
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg 100 mg 10 mg 1 mL x 10 mM (in DMSO)
Category	Oncology Reagents & Chemicals Molecules By Organ Lung Cancer
Type	Molecules
Specific against	other
Smiles	COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Nutlin3
Shipping Condition	Cool pack
Available
Manufacturer - Targets	E1/E2/E3 Enzyme
Storage Conditions	-20
Molecular Weight	581.49
Description	Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.
Pathways	Ubiquitination

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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