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GW 583340 dihydrochloride

GW 583340 dihydrochloride

Item no.	TMO-T22827-25mg
Manufacturer	TargetMol
CASRN	1173023-85-2
Amount	25 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Smiles	O=S(C)(CCNCC1=NC(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OCC5=CC(F)=CC=C5)N=CN=C3C=C2)=CS1)=O.Cl.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	GW583340 dihydrochloride
Shipping Condition	Cool pack
Available
Manufacturer - Targets	EGFR
Storage Conditions	-20
Molecular Weight	671.03
Description	GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 (epidermal growth factor receptor/tyrosine kinase) inhibitor and is capable of reversing ABCG2- and ABCB1-mediated resistance.GW 583340 dihydrochloride selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, and inhibits 80% of tumor growth in a mouse xenograft model, with potential anticancer activity.
Pathways	Tyrosine Kinase/Adaptors\|\|\|Angiogenesis\|\|\|JAK/STAT signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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