Desoxymetasone

RT

376, 46

White to off-white crystalline powder

Glucocorticoid anti-inflammatory. It is also found as an impurity in Dexamethasone.

Synonyms:
(11β, 16α)-9-Fluoro-11, 21-dihydroxy-16-methyl-pregna-1, 4-diene-3, 20-dione; 17-Deoxydexamethasone; 9-Fluoro-16α-methyl-1-corticosterone; Desoximetasone; Stidex; Topicort; Topicorte; Topisolon

CAS Number:
382-67-2

Molecular Formula:
C₂₂H₂₉FO₄

Molecular Weight:
376.46

Appearance:
White to off-white crystalline powder

Purity:
97-103%

Identification A, B:
Conforms

Residue on Ignition:
≤0.2%

Melting Point:
206-218ºC

Heavy Metals:
≤0.002%

Residual Solvent:
Methanol: ≤3000ppm
Dichloromethane: ≤600ppm
Ethyl Acetate: ≤5000ppm

Specific Optical Rotation:
+107 to +112°

Solubility:
Chloroform (Slightly), Methanol (Slightly)

Loss on Drying:
≤1%

Particle Size:
99% (<30 micron)

Storage:
4°C

Meets or exceeds USP39