PF 477736

Biochemicals / Biochem-Inhibitors

4°C

Highly Purified

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.

Synonyms:
(αR)-α-Amino-N-[5, 6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4, 3, 2-ef][2, 3]benzodiazepin-8-yl]cyclohexaneacetamide

CAS Number:
952021-60-2

Molecular Weight:
419.48

Molecular Formula:
C₂₂H₂₅N₇O₂

Storage and Stability:
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Pfizer Compound