(-)-Bicuculline Methochloride

Blue Ice

417, 85

Off white solid

Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Synonym:
[R-(R*, S*)]-5-(6, 8-Dihydro-8-oxofuro[3, 4-e]-1, 3-benzodioxol-6-yl)-5, 6, 7, 8-tetrahydro-6, 6-dimethyl-1, 3-dioxolo[4, 5-g]isoquinolinium chloride

CAS Number:
53552-05-9

Molecular Formula:
C₂₁H₂₀ClNO₆

Molecular Weight:
417.85

Appearance:
Off white solid

Purity:
≥99% (HPLC)

TLC [(Pyridine:Acetic acid:Water:Butanol [3:8:11:33])]
Rf = 0.46

HPLC:
>99.9%

1H NMR:
Consistent with structure

Mass Spectrum:
Consistent with structure

Microanalysis:
Carbon Hydrogen Nitrogen Theoretical 56.7 5.21 3.15

Solubility:
Water to 100mM
PBS to 100mM

Storage:
RT