Ellipticine (NSC 71795)

RT

246, 3

Supplied as a crystalline solid.

Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7uM.

Alternate Names:
5, 11-dimethyl-6H-pyrido[4, 3-b]carbazole, NSC 71795

CAS Number:
519-23-3

Molecular Formula:
C17H14N2

Molecular Weight:
246.3

Solubility:
~0.25mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2); ~1mg/ml in EtOH; ~10mg/ml in
DMSO and DMF

Purity:
≥98%

λmax:
247, 276, 294nm

Form:
Supplied as a crystalline solid.

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.