Amdinocillin

RT

325, 43

White to off-white powder

Amdinocillin is a semisynthetic antibiotic with broad-spectrum activity that is part of the aminopenicillin family. It is used in the treatment of bacterial infections such as those caused by Gram-negative bacteria, and to treat methicillin-resistant Staphylococcus (MRSA). The clinical isolate Amdinocillin has an inhibitory concentration (IC) of 0.25ug/mL against Enterobacter aerogenes and Enterobacter cloacae, and it displays a synergistic effect in combination with other antibiotics. The mechanism of action is that prevents bacterial growth and proliferation by inhibiting cell wall synthesis and causing lysis, which allows for drug therapy against specific types of bacteria.

Synonyms:
(2S, 5R, 6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; FL-1060, ro-9070, mecillinam, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]penicillanic acid; Mecillinam; FL 1060; Penicillin Hx

CAS No:
32887-01-7

Molecular Formula:
C15H23N3O3S

Molecular Weight:
325.43

Appearance:
White to off-white powder

Purity:
≥95%

Melting Point:
>143°C

Solubility:
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Storage and Stability:
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.