Acetylcholine Chloride (ACh)

RT

181, 66

White to off-white solid

Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform.

Acetylcholine chloride, injected at 20mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Synonyms:
2-(Acetyloxy)-N, N, N-trimethylethanaminium chloride; 2-Acetoxyethyltrimethylammonium chloride; N-(2-Hydroxyethyl)trimethylammonium chloride acetate; Acecoline; Arterocoline; Miochol; Ovisot

CAS No:
60-31-1

Molecular Formula:
C₇H₁₆ClNO₂

Molecular Weight:
181.66

Purity (Titration):
≥99%

Appearance:
White to off-white solid

Melting Point:
As reported

Loss on Drying:
≤1%

Solubility:
Chloroform (Slightly), Methanol (Slightly)

Storage and Stability:
Store at RT under inert atmosphere. Very Hygroscopic.