Imiquimod

RT

240, 3

White crystalline powder

Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Approved treatment for external genital warts caused by human papillomavirus infection.

Synonyms:
4-Amino-1-isobutyl-1H-imidazo(4, 5-c)quinoline; S26308; R-837

CAS Number:
99011-02-6

Molecular Weight:
240.30

Molecular Formula:
C14H16N4

Appearance:
Supplied as a white to off-white powder.

Purity:
≥98%

Solubility:
DMSO or dimethylformamide. Insoluble in ethanol. Slightly soluble in water.

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.