S-(5'-Adenosyl)-L-homocysteine Dihydrate

Biochemicals / Biochem-Nucleotides, Derivatives

-20°C

Highly Purified

S-(5'-Adenosyl)-L-homocysteine dihydrate is the active form of homocysteine. It has been shown to inhibit the growth of HL-60 cells and induce apoptosis in these cells. S-(5'-Adenosyl)-L-homocysteine dihydrate binds to dsDNA as a methyltransferase inhibitor, which leads to DNA methylation and inhibits DNA binding. The inhibition of DNA binding prevents transcription, leading to cell death. This drug has also been shown to have an anti-atherosclerotic effect in a model system by inhibiting the adenosine receptor.

Synonyms:
S-(5'-Deoxyadenosin-5'-yl)-L-homocysteine; L-5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine; Adenosyl-L-homocysteine; Adenosylhomocysteine; L-S-Adenosylhomocysteine; S-Adenosyl-L-homocysteine; S-Adenosylhomocysteine

CAS No:
979-92-0

Molecular Formula:
C₁₄H₂₀N₆O₅S

Molecular Weight:
384.41

Purity:
≥97%

Appearance:
White to light yellow solid

1H-NMR Spectrum:
Conforms to structure

Melting Point:
>175°C (dec.) (lit)

Optical Rotation (C=0.5 1M HCl):
As Reported

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.