RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor

Blue Ice

278, 33

White to off-white solid

Cell-permeable. A potent, selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2uM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Synonyms:
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

CAS No:
29925-17-5

Molecular Formula:
C15H22N2O3

Molecular Weight:
278.33

Appearance:
White to off-white solid

Purity:
≥95%

Solubility:
DMSO (~200mg/ml) or EtOH (~40mg/ml).

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Light sensitive.