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Description: NSC23766 3HCl, the salt form of NSC23766, is a novel and potent inhibitor of Rac GTPase, it targets the Rac activation by guanine nucleotide exchange factors (GEFs) with an IC50 of ca.50 uM in a cell-free assay; NSC23766 does not inhibit Cdc42 or RhoA, the closely related targets.
References: Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7618-23; J Biol Chem. 2005 Nov 11; 280(45):37516-25.
Related CAS: 733767-34-5 (free base)
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