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Pifithrin-α (PFTα) HBr

Pifithrin-α (PFTα) HBr

Item no.	V0014-500mg
Manufacturer	InvivoChem LLC
CASRN	63208-82-2
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0014CAS #:63208-82-2Purity >=98% Description: Pifithrin-alpha ((PFTalpha) is a novel and potent inhibitor of p53, acting by inhibiting p53 protein transcription and p53-dependent transactivation of p53-responsive genes. It also acts as an aryl hydrocarbon receptor (AhR) agonist. Pifithrin-alpha was firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. Pifithrin-alpha can also induce cell cycle arrest and growth arrest of embryonic stem cells. Treatment of Pifithrin-alpha significantly downregulates the protein lever of Nanog (a pluripotency marker). It is proved that the inhibition of p53 activity caused by Pifithrin-alpha has no effect on ES cell viability. Reference: Science. 1999 Sep 10; 285(5434):1733-7.
Molecular Weight (MW)	367.3
Formula	C16H18N2OS.HBr
CAS No.	63208-82-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (182.41 mM)
	Water:< 1 mg/mL (slightly soluble or insoluble)
	Ethanol: 2 mg/mL (6.08 mM)
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SMILES Code	CC1=CC=C(C(CN2C(SC3=C2CCCC3)=N)=O)C=C1.[H]Br
Synonyms	Pifithrin-alpha; Pifithrin alpha; PFTalpha; PFTalpha; PFT alpha

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Amount: 500 mg

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