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Apremilast (CC10004)

Apremilast (CC10004)

Item no.	V0082-1g
Manufacturer	InvivoChem LLC
CASRN	608141-41-9
Amount	1 g
Quantity options	100 mg 250 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0082CAS #:608141-41-9 Purity >=98% Description: Apremilast (also known as CC-10004), a thalidomide analog, is a novel and orally bioavailable small molecule inhibitor of the phosphodiesterase 4 (PDE4) with potential anti-inflammatory activity. It regulates inflammation through multiple cAMP downstream effectors. Apremilast inhibits PDE4 with an IC50 of 74 nM using 1 uM cAMP as substrate. Apremilast inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. Apremilast was approved by the FDA in 2014 for treatment of adults with active psoriatic arthritis. It is also being tested for its efficacy in treating other chronic inflammatory diseases such as ankylosing spondylitis, Behcet's disease, and rheumatoid arthritis. Description: References: Arthritis Res Ther. 2015 Sep 15; 17:249; References: Related CAS: 253168-86-4 Apremilast, (+/-)-; Otezla
Molecular Weight (MW)	460.50
Formula	C22H24N2O7S
CAS No.	608141-41-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility(In vitro)	DMSO: > 90 mg/mL
	Water: < 1 mg/mL
	Ethanol: 3 mg/mL
Chemical Name	(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1, 3-dioxoisoindolin-4-yl)acetamide
Synonyms	CC-10004; CC10004; Apremilast; CC 10004; Otezla (Trade name)
SMILES Code	CC(NC1=CC=CC(C(N2[CH](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O

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