PI-103

Item no.	V0107-25mg
Manufacturer	InvivoChem LLC
CASRN	371935-74-9
Amount	25 mg
Quantity options	100 mg 1 g 250 mg 500 mg 50 mg 5 mg
Category	Cardiovascular Research Heart Failure Hypertension Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0107CAS #:371935-74-9Purity >=98% Description: PI-103 is a novel and potent multi-targeted PI3K inhibitor for p110alpha/beta/delta/gamma with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, and has anticancer activity. It is less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 showed potent antiproliferation activities in various cancer cell lines such as prostate, ovary and glioblastoma. It exerted GI50 values of 0.14, 0.06, 0.13, 0.10, 0.12 and 0.08 uM in U87MG, IGROV-1, DETROIT-562, PC3, SKOV-3 and HUVEC cells, respectively. Description: Description: PI-103 is a novel and potent multi-targeted PI3K inhibitor for p110alpha/beta/delta/gamma with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, and has anticancer activity. It is less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 showed potent antiproliferation activities in various cancer cell lines such as prostate, ovary and glioblastoma. It exerted GI50 values of 0.14, 0.06, 0.13, 0.10, 0.12 and 0.08 uM in U87MG, IGROV-1, DETROIT-562, PC3, SKOV-3 and HUVEC cells, respectively. References: Mol Cancer Ther. 2009 Jul; 8(7):1725-38. References: References:
Molecular Weight (MW)	348.36
Formula	C19H16N4O3
CAS No.	371935-74-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 24 mg/mL (68.9 mM)
	Water:< 1 mg/mL (slightly soluble or insoluble)
	Ethanol: < 1 mg/mL (slightly soluble or insoluble)
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Chemical Name/Synonym	3-(4-morpholin-4-ylpyrido[2, 3]furo[2, 4-b]pyrimidin-2-yl)phenol; PI103; PI-103; PI 103

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Amount: 25 mg

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