TWS119

Item no.	V0214-250mg
Manufacturer	InvivoChem LLC
CASRN	601514-19-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0214CAS #:601514-19-6 Purity >=98% Description: TWS119, a pyrrolopyrimidine compound, is a novel, potent and selective/specific GSK-3beta (Glycogen synthase kinase-3beta) inhibitor with potential usefulness for in vivo stem cell biology and therapy. It inhibits GSK-3beta with an IC50 of 30 nM in a cell-free assay; it is capable of inducing neuronal differentiation and may be useful to stem cell biology. It is screened out from a library of pyrrolopyrimidines as a molecule that selectively induces neuronal differentiation when using mouse P19 EC cells. TWS119 binds to GSK-3beta tightly with a Kd value of 126nM. The combination of TWS119 and GSK-3beta modulates the activity of the complex and triggers downstream transcriptional events lead the neuronal induction. Besides that, TWS119 promotes neuronal differentiation of mESCs through another mechanism but not the canonical Wnt signaling pathway. Description:Description: TWS119, a pyrrolopyrimidine compound, is a novel, potent and selective/specific GSK-3beta (Glycogen synthase kinase-3beta) inhibitor with potential usefulness for in vivo stem cell biology and therapy. It inhibits GSK-3beta with an IC50 of 30 nM in a cell-free assay; it is capable of inducing neuronal differentiation and may be useful to stem cell biology. It is screened out from a library of pyrrolopyrimidines as a molecule that selectively induces neuronal differentiation when using mouse P19 EC cells. TWS119 binds to GSK-3beta tightly with a Kd value of 126nM. The combination of TWS119 and GSK-3beta modulates the activity of the complex and triggers downstream transcriptional events lead the neuronal induction. Besides that, TWS119 promotes neuronal differentiation of mESCs through another mechanism but not the canonical Wnt signaling pathway.GSK-3beta with an References:Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7632-7; Nat Biotechnol. 2004 Jul; 22(7):833-40. References:References: Related CAS: 1507095-58-0 (2 TFA salt)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 7 days

Compare

Add to wishlist

Get an offer